Mounted in a few decades after the events of the popular Anime film Blood: The Last Vampire, Amnesia Saya Otonasi lives as it would seem, a normal high school student with his reception desk on Okinawa. The terrible nightmares are the only signs of cruel life, which she once led, but her past is about to overtake it and wakes the ruthless warrior, which she carries inside. Chiropters: Powerful creatures that change the shape in which they need and eager humanity, which threatens blood again. And the mysterious organization called Red Shield needs deadly skills of silence and mysterious skills to help in the fight against these beasts. As his immersed abilities begin to wake up, and when he seeks to return his memories, the chiroper warriors are guided by the mysterious leader in order to threaten SAE and her loved ones.